Meta analysis of keluoxin capsule in the adjuvant treatment of diabetes nephropathy. In conclusion, our results show that UCG and CXC might be the optimum selection in UAER and ORR for patients with early DKD, and SSNT could be significantly superior to ACEI/ARB group in terms of Scr and AEs. BLC shows the best curative effect on 24 h UTP and Trig. TG shows the highest cost-effectiveness among nine CPMs. Although current estimates of the effects of most CPMs for DKD are significant and clinically relevant, enrolled reporting is not of high quality due to some information being missing. Thus, the use of these CPMs, including UCG, CXC, and BLC is worthy of further study, especially in terms of safety, and the evidence is currently insufficient to make any specific recommendations.

• DKD can be reversed, and the progression of the disease can be slowed if it is detected and treated at an early stage.
• Third, the trials that we included about TG , SYKFT , and KLX were too few, perhaps leading to publication bias.
• The league table of all comparisons of UAER and ORR.
• The icon seems be painted in egg tempera with gold leaf on wood (cypress?), prepared with gesso and linen.

Data are RRs (95% CI) for ORR (upper-right quadrant) and MDs (95% CI) for UAER (lower-left quadrant) in the column-defining treatment compared with the row-defining treatment. The random grouping method has been mentioned among all eligible studies except 18 RCTs (11.25%). In 44 RCTs (27.5%), a specific randomization method was described, including 35 RCTs that used randomization number tables; 3 RCTs used the drawing of lots; 3 RCTs used computer serial number; 1 RCT used tossing a coin; 1 RCT used random envelope; and 1 RCT used block randomization. All of them were classified as “low risk” in random sequence generation.

Research

First, 56 RCT studies (35%) clearly mentioned that included participants had type 2 diabetes. There were, however, 104 RCT studies that did not specify the type of diabetes participants had. Inconsistent types of diabetes among patients may lead to differing responses to drugs, causing deviations in data analysis. Second, for the same Chinese patent medicine, the dose taken by participants is not completely the same in the different RCT studies we included, which may have a certain impact on the final result. Third, the trials that we included about TG , SYKFT , and KLX were too few, perhaps leading to publication bias.

• BLC shows the best curative effect on 24 h UTP and Trig.
• Patients who were diagnosed with diabetes mellitus and met the diagnostic criteria of early diabetic kidney disease were included.
• As part of the study, the treatment group was given one of nine CPMs in combination with an ACEI or ARB.
• See a similar style of painted icon in Christie’s, Icons and Artefacts from the Orthodox World, Monday 24 November 2008, London, 2008.

In contrast with traditional meta-analyses, network meta-analysis offers greater value, which can rank multiple interventions simultaneously by combining direct and indirect comparison results . Therefore, a NMA to rank the effectiveness, safety, and cost of the nine CPMs for patients with early DKD was performed. Clinical decision makers can use the data we provide to determine what treatment is most appropriate for patients with early DKD based on evidence-based medicine. The China State Food and Drug Administration has approved all nine CPMs. Meta-analysis of efficacy of Compound Xueshuantong capsules combined with ACEI/ARB in treatment of diabetic kidney disease. With regard to TC, relying on the highest SUCRA of 90.2%, KLX was ranked first and could remarkably reduce the level of TC.

Small Order 1-23 Skeins Total CXC Individual – Colour Codes B5200, Ecru and Blanc 150-3866

Specific details about the results of statistical analysis on the Scr are displayed in Table 1. The value of SUCRA about UAER was 98.0, 74.3, 62.6, 61.0, 54.0, 51.4, 35.3, 33.9, 27.2, and 2.4% for UCG, TG, BLC, SYKFT, JSB, HKC, CXC, KLX, SSNT, and ACEI/ARB alone, respectively. Specific details about the results of statistical analysis on the UAER are displayed in Table 1. Flow chart of search and selection.

CRR was defined as the clinical symptoms disappearing or the urinary albumin excretion rate returning to normal or decreasing by more than 50%. PRR was defined as the clinical symptoms relieved or the urinary albumin excretion rate decreasing, but the decrease range was not obvious. Secondary outcomes include total cholesterol , triglyceride , and glycosylated hemoglobin, type A1c . Safety outcome was adverse effects .

TC was reported in 35 publications involving 7 CPMs and 3,015 patients. A total of eight interventions were included. Based on the value of SUCRA, KLX was ranked first (SUCRA of 90.2%), and the worst treatment was ACEI/ARB, with 0.5% of SUCRA . Two reviewers assessed the risk of bias for all included studies independently according to the Cochrane Risk of Bias tool [Cochrane Handbook for Systematic Reviews of Interventions, version 5.4.0] (Higgins et al., 2011).

At present, there are few strong head-to-head clinical trials on SSNT; therefore, SSNT deserves more attention in the future based on the related findings of this review. Diabetes mellitus is thought to lead to microvascular damage most frequently to kidneys (Thomas et al., 2015). There has been a quadrupling of people worldwide with diabetes mellitus in the past 30 years (Zheng et al., 2018). Diabetic kidney disease , the leading cause of end-stage renal disease in the world, affects about 40% of diabetes mellitus patients. In 1987, according to the pathophysiological characteristics and evolution process of DKD, Mogensen, a Danish scholar, divided DKD into five stages.

DKD, diabetic kidney disease; RCT, randomized clinical trial. We included RCTs in which they compared the efficacy of nine CPMs in combination with ACEI/ARB against ACEI/ARB alone in treating early DKD. Although there was no restriction on the language of RCTs, RCTs were required to include primary or secondary outcome indicators . The editor and reviewer’s affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. These are third party technologies used for things like interest based Etsy ads.

It is widely accepted that urinary albumin excretion rate can be used for diagnosis and clinical grading of DKD (Chen et al., 2017). The effective treatments of DKD mainly include general treatments, such as healthy lifestyle and dietary habit, and pharmaceutical treatments, such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers . In comparison with ACEI/ARB alone, several studies have suggested that traditional Chinese medicine in conjunction with ACEI/ARB has better efficacy with fewer side effects for patients with DKD (Xiao et al., 2013; Liu et al., 2014; Li and Xu, 2020).

Search in reviews, Q&A…

As part of the study, the treatment group was given one of nine CPMs in combination with an ACEI or ARB. Additionally, the control group was given an ACEI/ARB alone or an ACEI/ARB combined with any of eight other CPMs. Both groups continued to maintain general treatment, such as the management of blood pressure, blood glucose, and blood lipid.

All enrolled RCTs were performed in China and published between 2006 and 2022. The process of searching and selecting is presented in Figure 1. Despite this, there are a few inadequacies that should be considered when interpreting the results.

Each domain can be judged as high risk, low risk, or unclear risk for included studies. A third reviewer adjudicated any disagreements. We used endnote software to manage the retrieved literature.

CXC Threads similar to DMC, 200 random colours, no duplicates.

Taking the Chinese market price as the standard and 3 months as a course of treatment, we counted the cost of nine kinds of CPMs for one course of treatment of early DKD . In our expense statistics, we selected the conventional dosage for each Chinese patent medicine after referring to drug instructions. It should be added that we took 60 kg as the reference standard weight when we calculated the cost of TG. According to the result, TG was ranked first with the least cost , followed by SYKFT and CXC .

The style of the icon, although inscribed with Greek letters, and especially the faces of the divine figures recalls the Russian school. If a user or application submits more than 10 requests per second, further requests from the IP address may be limited for a brief period. Once How is materiality determined the rate of requests has dropped below the threshold for 10 minutes, the user may resume accessing content on SEC.gov. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website.

Among enrolled 13,365 participants, 6,713 patients in the treatment group received nine CPMs in combination with an ACEI/ARB, and 6,652 participants in the control group took only an ACEI/ARB. In 160 eligible RCTs, four trials did not mention the concrete duration of treatment in their texts. The longest, shortest, and mean duration of treatment were 24, 2, and 11.6 weeks, respectively. In treatment groups, BLC was utilized in 45 RCTs and 2016 patients with highest frequency , JSB , HKC , UCG , TG , CXC , SYKFT , KLX , and SSNT .

It should be noted that only one RCT observed the effects of SSNT and SYKFT in combination with ACEI/ARB on early DKD. Hence, more caution and prudence are needed to interpret https://cryptolisting.org/ the abovementioned result. At the same time, more RCTs with high-quality, large-sample, and multi-center about SSNT and SYKFT are needed to verify our findings in the future.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding author. HbA1c was reported in 34 publications involving 6 CPMs and 2,751 patients. Network plot is presented in Supplementary Figure S1G. Compared with ACEI/ARB alone, only two interventions, namely, JSB (−0.43 (−0.67, −0.20)) and HKC (−0.48 (−0.81, −0.13)), showed significant advantages in decreasing HbA1c according to Supplementary Figure S2G and Supplementary Figure S4. According to the value of SUCRA, HKC, JSB, and SSNT were ranked first, second, and third, with the SUCRA of 81.0, 77.9, and 88.7%, respectively .

Large bundles of CXC embroidery thread – Newest batch “2 label” pick your own colours! Matches DMC colours

Wang, X., Xue, B., Li, C., Chen, Q., Liu, H., Wang, T., et al. . Research progress on shenyan Kangfu tablets in treatment of diabetic nephropathy. Bo, L., Li, J., Zhao, J., Li, F., Wei, F., Wu, R., et al. .

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Megrega, Olonetsky district; Russia, Karelia, at the Museum of Fine Arts of the Republic of Karelia . 683 grams, 28 x 25 cm (11 x 9 7/8 in). Charterhouse auctioneers, Sherborne, Dorset, UK. Ian Wilkinson collection, Nottinghamshire, UK, formed since 1985. The icon seems be painted in egg tempera with gold leaf on wood (cypress?), prepared with gesso and linen. Red and black paint was also used for the frame of the icon in the shape of two simple narrow bands.

In addition to providing data about the frequency of the most common adverse effects, the systematic review provides a statistical comparison of the basics of large amounts of data. For the outcome of ORR, we are surprised that all the remedies demonstrated better therapeutic effect than ACEI/ARBA alone in ORR. Li et al. published similar results when compared ACEI/ARB alone with JSB + ACEI/ARB in ORR (Li et al., 2020). Actually, these nine Chinese patent medicines, regardless of their monomers or prescriptions, have been proven beneficial in treating DKD in animal and human experiments in China.

For Scr, SSNT had the best effect on treating early DKD among all nine CPMs, which was different from the findings of Zhao et al. . In their review, there was a significant decrease in SCr for CXC with the highest SUCRA. It is worth noting that only seven kinds of CPMs are involved, not including SSNT in their article. As far as we are concerned, this study is the first to include SSNT and compare its efficacy with other Chinese patent medicines. As an adjuvant treatment for chronic kidney failure, Cui et al. performed a meta-analysis of RCTs and determined that the SSNT group had better results than the control group in terms of clinical efficiency, such as Scr, which is consistent with our findings.

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